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Substance in Red Wine Shows Promise in First Human Study

Thanks Dan & Lorri for sending this article on. Posted at 12:00 PM ET, 11/01/2011 

By Rob Stein

resveratrol and benefits Study Points: Resveratrol red wine (so as Shaklee anti-aging tonic Vivix) has a variety of fundamental beneficial effects on subjects' metabolism.

  • Longevity,
  • protect from obesity and diabetes,
  • boost of physical endurance,
  • reduce blood sugar,
  • reduce blood pressure,
  • reduce triglycerides,
  • reduce¬†inflammation,
  • boost the efficiency of muscles.


A compound in red wine suspected of offering a host of health benefits has for the first time shown promise in a study testing the compound in people, researchers reported Tuesday. A compound in red wine produced a variety of fundamental beneficial effects on subjects' metabolism in a study, researchers reported Tuesday. (Deb Lindsey - For The Washington Post) The small but intensive study involving 11 obese but healthy men found that taking a relatively low dose of resveratrol daily for a month produced a variety of fundamental beneficial effects on their metabolism. "We are very excited," said Patrick Schrauwen of Maastricht University in The Netherlands, whose research was <http://www.cell.com/cell-metabolism/abstract/S1550-4131(11)00386-X> posted online by the journal Cell Metabolism. "We found a lot of effects that all point in the same direction of better metabolic health." Many scientists have been excited about resveratrol since studies in yeast, fruit flies and laboratory mice indicated the substance could mimic the benefits of consuming a very low-calorie diet, which has been shown to extend longevity in many species. Some people severely restrict their caloric intake in the hopes of living longer. But most people find it difficult if not impossible to adopt such a stringent lifestyle. Resveratrol also appeared to <http://www.washingtonpost.com/wp-dyn/content/article/2006/11/16/AR2006111600705.html> protect mice from obesity and diabetes, boost the animals' physical endurance, reduce their chances of suffering the ill effects of obesity and extend their lives. Such findings prompted some scientists to speculate that the presence of trace amounts of resveratrol in red wine might help explain the "French paradox," which is that the French consume a relatively rich diet, but live as long as anyone else. Some people have even started taking resveratrol, which is sold over-the-counter in health and grocery stores. But the benefits for people have never been shown and the potential risk of high doses for long periods remains unknown and some scientists have questioned the validity of some of the early research. In the new study, Schrauwen gave 150 milligrams or a placebo to the healthy obese men for 30 days and then switched those on placebo to resveratrol and vice versa for another month. Each time they conducted a series of detailed tests to examine the impact on their metabolism. Resveratrol appeared to produce all the same effects in the human subjects as it had in animals, such as lowering the metabolic rate, cutting the accumulation of fat in the liver, reducing blood sugar, blood pressure, triglycerides and inflammation and boosting the efficiency of muscles. There were no apparent side effects. "I think it's very promising," said Rafael de Cabo of the National Institute on Aging, who has been studying resveratrol in monkeys."It's very significant." The researchers noted that the dose was much lower than that used in animal studies and the amount many people take on their own. But someone would have to drink at least about two gallons of red wine a day to get the equivalent amount of resveratrol. The findings were praised by other researchers who have been studying resveratrol and other compounds that increase proteins known as sirtuins thought to have the beneficial effects. "This study comes at a time when obesity and diabetes are reaching epidemic proportions," said David A. Sinclair of Harvard Medical School. "Sirtuins offer the promise that we can find ways to prevent the effects of obesity and sedentary lifestyles." "This paper is important," said Leonard P. Guarante, who studies aging at the Massachusetts Institute of Technology. "It suggests that sirtuin-based drugs is a promising new strategy to treat human diseases." Schrauwen and others cautioned, however, that much more research is needed to follow up on the study to determine if resveratrol's effects translate into health benefits, especially for those who are not obese, and whether it is safe over the long term. "Although it is a bit early, we may soon find ourselves looking back on the discovery and development of resveratrol ... and other related small molecules that can delay age-related disorders and improve healthy life span as a truly historic point in aging research," said Stephen Helfand of Brown University. "The finding of molecules with such dramatic positive effects on age-related disorders and life span is a major conceptual leap forward for the field of aging research, perhaps equivalent to the effect of the discovery of antibiotics on treating infectious diseases," Helfand said. "It is an extraordinary time to be involved in research on the biology of aging."

anti aging tonic vivixGO BEYOND JUST RESVERATROL FOR EVEN GREATER RESULTS (see the enclosed cellular energy field ... when Vivix is used the mitochondria multiplies greatly) PLEASANTON, CA -- 08/10/10 -- Can a supplement with resveratrol AND polyphenols boost cellular energy and metabolism? Researchers at the University of Tennessee, Knoxville and Shaklee Corporation have partnered to address these questions by studying the impact of a unique blend of resveratrol and muscadine polyphenols found in Shaklee VIVIX Cellular Anti-Aging* dietary supplement, on human muscle cell mitochondria, the intra-cellular power plants that generate cellular energy. With this research, Dr. Jamie McManus, Chairman of Medical Affairs, Health Sciences and Education at Shaklee, and Dr. Michael Zemel of the University of Tennessee are seeking to determine the impact of this unique polyphenol blend on key biological processes related to cellular energy production and aging. "One of the key mechanisms of aging is a decline in mitochondrial mass as well as the effectiveness of the mitochondria," said Dr. McManus. "In our research, we are trying to validate the impact of VIVIX polyphenols on mitochondrial biogenesis -- shorthand for how the number and size of mitochondria help create cellular energy and boost metabolism. We are excited to share our research goals with the medical community and create a baseline for future studies on polyphenols and cellular energy metabolism." VIVIX was developed by Shaklee scientists by combining resveratrol with an extract from the only grape in nature that contains an extra chromosome. This muscadine super grape has polyphenols that complement the many benefits of resveratrol. Shaklee scientists created a unique profile of polyphenols shown in laboratory studies to positively impact multiple mechanisms of cellular aging.

Thanks Dan & Lorri for sending this article on. Posted at 12:00 PM ET, 11/01/2011 

By Rob Stein

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